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Hypertens Pregnancy. 2011;30(2):231-42. doi: 10.3109/10641955.2010.484085. Epub 2010 Aug 11.

Skin autofluorescence as marker of tissue advanced glycation end-products accumulation in formerly preeclamptic women.

Author information

1
Department of Obstetrics and Gynecology, University Medical Center Groningen, Hanzeplein 1, Groningen, The Netherlands. s.m.coffeng@student.rug.nl

Abstract

CONDENSATION:

In women with a history of preeclampsia skin autofluorescence as marker of tissue AGEs accumulation is increased, supporting a common causal metabolic or vascular link between preeclampsia and cardiovascular diseases.

OBJECTIVE:

To investigate whether skin autofluorescence (AF), as marker of tissue accumulation of advanced glycation end-products (AGEs), is elevated in women with a 4-year history of severe preeclampsia.

METHODS:

About 17 formerly preeclamptic women and 16 controls were included. Skin AF and several traditional cardiovascular risk factors were recorded.

RESULTS:

In comparison to controls, formerly preeclamptic women had higher skin AF of the legs, body mass index (BMI), blood pressure, and high-sensitivity C-reactive protein (hsCRP), HbA1C, and triglycerides in serum.

CONCLUSION:

Skin AF as well as cardiovascular risk factors is elevated in formerly preeclamptic women. These results suggest a common causal vascular link between preeclampsia and cardiovascular diseases.

PMID:
20701478
DOI:
10.3109/10641955.2010.484085
[Indexed for MEDLINE]

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