Format

Send to

Choose Destination
J Autism Dev Disord. 2011 May;41(5):618-27. doi: 10.1007/s10803-010-1079-7.

Maternal early life factors associated with hormone levels and the risk of having a child with an autism spectrum disorder in the nurses health study II.

Author information

1
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.

Erratum in

  • J Autism Dev Disord. 2011 May;41(5):628. Santangelo, Susan [corrected to Santangelo, Susan L].

Abstract

It is not known whether reproductive factors early in the mother's life influence risk of autism spectrum disorders (ASD). We assessed maternal age at menarche, menstrual cycle characteristics during adolescence, oral contraceptive use prior to first birth, body shape, and body mass index (BMI) in association with ASD using binomial regression in a cohort study of 61,596 women, including 743 cases. Overall, early life factors were not associated with ASD, though early age at menarche (RR for age 10 or less = 1.54, 95% CI 1.18, 2.02, p = 0.0002) and BMI at age 18 of ≥30 (RR 2.03, 95% CI 1.34, 3.08, p = 0.0008) were significantly associated with increased risk of ASD. Further work should investigate the potential influence of these factors.

PMID:
20700638
PMCID:
PMC3494408
DOI:
10.1007/s10803-010-1079-7
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center