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Nat Rev Mol Cell Biol. 2010 Sep;11(9):668-74. doi: 10.1038/nrm2956. Epub 2010 Aug 11.

New functions of aminoacyl-tRNA synthetases beyond translation.

Author information

1
Min Guo, Xiang-Lei Yang and Paul Schimmel are at The Skaggs Institute for Chemical Biology and Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

Abstract

Over the course of evolution, eukaryotic aminoacyl-tRNA synthetases (aaRSs) progressively incorporated domains and motifs that have no essential connection to aminoacylation reactions. Their accretive addition to virtually all aaRSs correlates with the progressive evolution and complexity of eukaryotes. Based on recent experimental findings focused on a few of these additions and analysis of the aaRS proteome, we propose that they are markers for aaRS-associated functions beyond translation.

PMID:
20700144
PMCID:
PMC3042954
DOI:
10.1038/nrm2956
[Indexed for MEDLINE]
Free PMC Article

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