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Br J Cancer. 2010 Sep 28;103(7):1085-8. doi: 10.1038/sj.bjc.6605843. Epub 2010 Aug 10.

Prevalence and risk factors for esophageal squamous cell cancer and precursor lesions in Anyang, China: a population-based endoscopic survey.

Author information

1
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Laboratory of Genetics, Peking University School of Oncology, Beijing Cancer Hospital & Institute, 52 Fucheng Rd. Hai Dian District, 100142 Beijing, People's Republic of China.

Abstract

BACKGROUND:

The etiology of esophageal squamous cell cancer (ESCC) in high prevalence regions of China remains unclear.

METHODS:

Endoscopic biopsies were conducted among 7381 inhabitants aged from 25 to 65 of Anyang, China.

RESULTS:

In this study, 2.57, 0.20 and 0.16% of the participants had mild, moderate and severe squamous dysplasia, respectively; 0.19 and 0.08% showed squamous carcinoma in situ and invasive ESCC. Using deep well (depth >100 meters) as water source (odds ratio=0.72, 95% confidence interval: 0.54-0.96) was negatively associated with ESCC and its precursors, whereas tobacco and alcohol use were not significantly associated with ESCC.

CONCLUSIONS:

Water source and other factors in this region need further evaluation by longitudinal studies.

PMID:
20700119
PMCID:
PMC2965859
DOI:
10.1038/sj.bjc.6605843
[Indexed for MEDLINE]
Free PMC Article

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