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ACS Chem Biol. 2010 Oct 15;5(10):905-17. doi: 10.1021/cb1001558.

Describing the mechanism of antimicrobial peptide action with the interfacial activity model.

Author information

1
Department of Biochemistry SL43, Tulane University Health Sciences Center, New Orleans, Louisiana 70112-2699, USA. wwimley@tulane.edu

Abstract

Antimicrobial peptides (AMPs) have been studied for three decades, and yet a molecular understanding of their mechanism of action is still lacking. Here we summarize current knowledge for both synthetic vesicle experiments and microbe experiments, with a focus on comparisons between the two. Microbial experiments are done at peptide to lipid ratios that are at least 4 orders of magnitude higher than vesicle-based experiments. To close the gap between the two concentration regimes, we propose an "interfacial activity model", which is based on an experimentally testable molecular image of AMP-membrane interactions. The interfacial activity model may be useful in driving engineering and design of novel AMPs.

PMID:
20698568
PMCID:
PMC2955829
DOI:
10.1021/cb1001558
[Indexed for MEDLINE]
Free PMC Article
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