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Appl Opt. 2010 Aug 10;49(23):4343-54. doi: 10.1364/AO.49.004343.

Multi-projection fluorescence optical tomography using a handheld-probe-based optical imager: phantom studies.

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Department of Biomedical Engineering, Optical Imaging Laboratory, EC 2675, Florida International University, 10555 West Flagler Street, Miami, Florida 33174, USA.


A handheld-probe-based optical imager has recently been developed toward three-dimensional tomography. In this study, the improvement of target depth recovery was demonstrated using a multi-projection technique on large slab phantoms using 0.45 cc fluorescing target(s) (with 1:0 contrast ratio) of 1.5 to 2.5 cm deep. Tomographic results using single- and multi- (here dual) projection measurements (with and without a priori information of target location) were compared. In all experimental cases, the use of multi-projection measurements along with a priori information recovered target depth and location closer to their true values, demonstrating its applicability for clinical translation.

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