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Ann Saudi Med. 2010 Sep-Oct;30(5):404-7. doi: 10.4103/0256-4947.67087.

Evolution of tigecycline resistance in Klebsiella pneumoniae in a single patient.

Author information

1
King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. nalqadheeb@kfshrc.edu.sa

Abstract

Carbapenemase-producing Klebsiella pneumoniae infections carry serious clinical and infection-control implications. Isolates possessing such hydrolyzing enzymes have been described in the United States and around the world. Besides being resistant to carbapenems, they usually confer resistance to fluoroquinolones, piperacillin-tazobactam, and extended-spectrum cephalosporins. Tigecycline demonstrates in vitro activity against these organisms, but reported resistance raises concern about tigecycline use for these infections. We describe a carbapenemase-producing K pneumoniae evolving resistance to tigecycline in a 75-year-old male after a prolonged stay in a critical care unit.

PMID:
20697161
PMCID:
PMC2941256
DOI:
10.4103/0256-4947.67087
[Indexed for MEDLINE]
Free PMC Article

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