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Immunol Today. 1991 Mar;12(3):A38-41.

Heat shock proteins in host-parasite interactions.

Author information

1
Allergy Unit, University Hospital, Geneva, Switzerland.

Abstract

For most living organisms, heat shock represents an unusual stress situation, but for parasites that are transmitted between invertebrate vectors and mammalian hosts it is a frequent physiological occurrence. Because of the extraordinary conservation of heat shock proteins (HSPs) and their potential immunogenicity, much attention has recently focused on the role of HSPs in infection and immunity. In parasites, HSPs appear to play specific functions in differentiation, in protection from the host cell's killing mechanisms, including oxygen free radicals, and even in virulence. In this article, Barbara Polla uses the example of malaria to illustrate the possible role of HSPs in host-parasite relationships.

PMID:
2069677
DOI:
10.1016/S0167-5699(05)80011-8
[Indexed for MEDLINE]

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