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Neuron. 2010 Aug 12;67(3):352-4. doi: 10.1016/j.neuron.2010.07.025.

Signaling endosomes trigger synapse assembly.

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1
Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA. jason_newbern@med.unc.edu

Abstract

In this issue of Neuron, Sharma et al. report that target-derived NGF exerts long-distance control of postsynaptic assembly. A major advance is the discovery that TrkA signaling endosomes are retrogradely transported to neuronal dendrites and directly trigger the clustering of postsynaptic density proteins.

PMID:
20696371
DOI:
10.1016/j.neuron.2010.07.025
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