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Biochem Biophys Res Commun. 1991 Jul 15;178(1):16-23.

Dexamethasone and 2,3,7,8-tetrachlorodibenzo-p-dioxin can induce thymic atrophy by different mechanisms in mice.

Author information

1
Department of Toxicology, Uppsala University, Sweden.

Abstract

The effects of in vivo exposure to dexamethasone (DEX) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on thymocyte proliferation and thymocyte number were compared. In the thymus of DEX-treated mice (1 mg/kg) both proliferation and cell number had decreased by 70% one day after exposure. This decrease was, however, transient, and values returned to normal within 2 weeks. By contrast, in TCDD exposed mice (50 micrograms/kg), a reduction in proliferation was not observed until day 2 after exposure, and the degree of reduction was only about 50%. By this point in time, cell number had only decreased by 20%. Proliferation increased again on day 3 after TCDD administration, whereas cell number continued to decrease and remained low throughout the observation period (8 days). DEX had a direct and immediate effect on cells in all thymocyte subpopulations whereas TCDD initially only affected the immature double negative (DN) and double positive (DP) populations.

PMID:
2069555
DOI:
10.1016/0006-291x(91)91773-6
[Indexed for MEDLINE]

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