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Nat Neurosci. 2010 Sep;13(9):1053-5. doi: 10.1038/nn.2613. Epub 2010 Aug 8.

A calcineurin/AKAP complex is required for NMDA receptor-dependent long-term depression.

Author information

1
Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California, USA.

Abstract

AKAP79/150 is a protein scaffold that is thought to position specific kinases (protein kinase A and C) and phosphatases (calcineurin) in appropriate synaptic domains so that their activities can regulate excitatory synaptic strength. Using a viral-mediated molecular replacement strategy in rat hippocampal slices, we found that AKAP is required for NMDA receptor-dependent long-term depression solely because of its interaction with calcineurin.

PMID:
20694001
PMCID:
PMC2943866
DOI:
10.1038/nn.2613
[Indexed for MEDLINE]
Free PMC Article

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