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Int J Comput Biol Drug Des. 2010;3(1):52-67. doi: 10.1504/IJCBDD.2010.034499. Epub 2010 Aug 5.

Identifying genes progressively silenced in preneoplastic and neoplastic liver tissues.

Author information

1
Department of Biostatistics, Virginia Commonwealth University, Richmond, Virginia 23298-0032, USA. kjarcher@vcu.edu

Abstract

High-throughput genomic technologies are increasingly being used to identify therapeutic targets and risk factors for specific diseases. Using 116 independent liver samples, we identified 793 probe sets that demonstrated a significant association in the frequency of absent calls as tissues progressed from normal to pre-neoplastic to neoplastic, followed by a bioinformatic approach which identified that 78.9% of the significant probe sets contained at least one CpG island in the gene promoter region compared with 58.9% of the remaining genes examined. Our results indicate that further high-throughput methylation studies to more fully characterize molecular events involved in hepatocarcinogenesis are warranted.

PMID:
20693610
PMCID:
PMC3740367
DOI:
10.1504/IJCBDD.2010.034499
[Indexed for MEDLINE]
Free PMC Article
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