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J Mol Cell Biol. 2010 Oct;2(5):237-9. doi: 10.1093/jmcb/mjq016. Epub 2010 Aug 5.

A new avenue to cure cancer by turning adaptive immune T cells to innate immune NK cells via reprogramming.

Author information

1
Department of Biomedical Research, University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA. dong-ming.su@uthct.edu

Abstract

Thymocytes after T-lineage commitment develop in the T-cell pathway. However, in a recent study, Li et al. (2010) demonstrated that inducing to delete Bcl11b gene in these thymocytes, even in mature T cells turns these cells into natural killer (NK) cells during the culture. They called this conversion 'reprogramming', and the reprogrammed killer cells 'ITNK cells'. The ITNK cells possessed tumor-killer ability and did not indiscriminately kill normal cells. This exciting finding represents a major breakthrough towards curing cancer and identifies an important, novel transcription factor in the thymus development.

PMID:
20693167
PMCID:
PMC2952389
DOI:
10.1093/jmcb/mjq016
[Indexed for MEDLINE]
Free PMC Article
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