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J Gynecol Obstet Biol Reprod (Paris). 2010 Dec;39(8):601-5. doi: 10.1016/j.jgyn.2010.06.010. Epub 2010 Aug 7.

[Contributions of the ex vivo human perfused placenta in the study of placental transfer of drugs].

[Article in French]

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1
Service de gynécologie-obstétrique, hôpital Beaujon, GHU Nord, AP-HP, université Paris-7, 100, boulevard du Général-Leclerc, 92100 Clichy, France. pfceccaldi@gmail.com

Abstract

Perfused human placental lobule was developed during the 1970s. Only this model respects the anatomical features of the human placenta. This approach allows different technical conditions (concentrations of drugs…) without ethical problems. Limitations of this ex vivo model are detailed in this review, also its recent contributions in better understanding of placental passage of drugs.

PMID:
20692775
DOI:
10.1016/j.jgyn.2010.06.010
[Indexed for MEDLINE]
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