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Am J Ophthalmol. 2010 Oct;150(4):511-8. doi: 10.1016/j.ajo.2010.05.024. Epub 2010 Aug 5.

Patients with an acute zonal occult outer retinopathy-like illness rapidly improve with valacyclovir treatment.

Author information

1
Department of Ophthalmology and Visual Sciences, Carver Family Center for Macular Degeneration, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA.

Abstract

PURPOSE:

To describe 3 cases of an acute zonal occult outer retinopathy-like illness responsive to valacyclovir hydrochloride.

DESIGN:

Retrospective, interventional case series.

METHODS:

Three patients were treated with valacyclovir and monitored by clinical examination, Goldmann visual field testing, and electroretinography.

RESULTS:

Patients with an acute zonal occult outer retinopathy-like illness presented following progressive vision loss. This course was immediately reversed by treatment with oral valacyclovir, and visual acuity and visual field improved significantly at 1 week and 1 month. Patients remained stable without treatment during a follow-up period ranging from 1 to 3 years.

CONCLUSIONS:

Some conditions with features of acute zonal occult outer retinopathy may be attributable to a subacute herpetic viral infection that is responsive to oral antiviral medication.

PMID:
20691421
PMCID:
PMC4669885
DOI:
10.1016/j.ajo.2010.05.024
[Indexed for MEDLINE]
Free PMC Article

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