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Am J Ophthalmol. 2010 Nov;150(5):628-36. doi: 10.1016/j.ajo.2010.05.015. Epub 2010 Aug 5.

Identification of new pathogens in the intraocular fluid of patients with uveitis.

Author information

1
Department of Virology, University Medical Center Utrecht, The Netherlands. J.D.FdeGroot@umcutrecht.nl

Abstract

PURPOSE:

To determine infectious causes in patients with uveitis of unknown origin by intraocular fluids analysis.

DESIGN:

Case-control study.

METHODS:

Ocular fluids from 139 patients suspected of infectious uveitis, but negative for herpes simplex virus, varicella-zoster virus, cytomegalovirus, and Toxoplasma gondii by polymerase chain reaction and/or antibody analysis in intraocular fluids, were assessed for the presence of 18 viruses and 3 bacteria by real-time polymerase chain reaction (PCR). The ocular fluids from 48 patients with uveitis of known etiology or with cataract were included as controls.

RESULTS:

Positive PCR results were found for Epstein-Barr virus, for rubella virus, and for human herpesvirus 6 each in 1 patient and for human parechovirus in 4 patients. Of the human parechovirus-positive patients, 1 was immunocompromised and had panuveitis. The other 3 patients were immunocompetent and had anterior uveitis, all with corneal involvement.

CONCLUSIONS:

Human parechovirus might be associated with infectious (kerato)uveitis.

Comment in

PMID:
20691420
DOI:
10.1016/j.ajo.2010.05.015
[Indexed for MEDLINE]
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