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Gynecol Oncol. 2010 Sep;118(3):289-94. doi: 10.1016/j.ygyno.2010.05.022. Epub 2010 Jun 18.

Dietary consumption of antioxidant nutrients and risk of incident cervical intraepithelial neoplasia.

Author information

1
Risk Assessment, Detection and Intervention Program, Moffitt Cancer Center, Tampa, FL 33612, USA.

Abstract

OBJECTIVE:

Women with human papillomavirus (HPV) infections are at risk for developing squamous intraepithelial lesions (SIL) of the cervix; however, other factors are required for infections to progress to SIL. We hypothesize that consumption of fruits and vegetables high in antioxidant nutrients may prevent, in part, the development of HPV-associated SIL.

METHODS:

This study is a nested case-control study of 265 HPV-positive women (93 SIL cases and 172 cytologically normal controls) in the Ludwig-McGill Cohort Study, São Paulo, Brazil. Diet was assessed by a self-administered food frequency questionnaire. The association between food and nutrient intake of antioxidants and incident SIL was determined by logistic regression and multinomial regression when comparing LSIL and HSILs.

RESULTS:

Higher reported consumption of papaya was inversely associated with risk of SIL (p trend=0.01) and strongest for >or=1 time/week (adjusted odds ratios (AORs)=0.19; 95%CI, 0.08-0.49). Risk of SIL was reduced among women reporting consumption of oranges >or=1 time/week (AOR=0.32; 95%CI, 0.12-0.87; p-trend=0.02). Nutrient intakes of ss-cryptoxanthin and alpha-carotene were marginally protective against SIL.

CONCLUSIONS:

Frequent consumption of fruits high in antioxidant nutrients appears to be associated with reduced risk of incident SIL among Brazilian women.

PMID:
20691333
PMCID:
PMC3691953
DOI:
10.1016/j.ygyno.2010.05.022
[Indexed for MEDLINE]
Free PMC Article

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