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FEBS Lett. 2010 Sep 10;584(17):3703-8. doi: 10.1016/j.febslet.2010.07.057. Epub 2010 Aug 5.

Collaboration and competition between DNA double-strand break repair pathways.

Author information

1
Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

Abstract

DNA double-strand breaks resulting from normal cellular processes including replication and exogenous sources such as ionizing radiation pose a serious risk to genome stability, and cells have evolved different mechanisms for their efficient repair. The two major pathways involved in the repair of double-strand breaks in eukaryotic cells are non-homologous end joining and homologous recombination. Numerous factors affect the decision to repair a double-strand break via these pathways, and accumulating evidence suggests these major repair pathways both cooperate and compete with each other at double-strand break sites to facilitate efficient repair and promote genomic integrity.

PMID:
20691183
PMCID:
PMC3954739
DOI:
10.1016/j.febslet.2010.07.057
[Indexed for MEDLINE]
Free PMC Article

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