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BMC Res Notes. 2010 Aug 6;3:221. doi: 10.1186/1756-0500-3-221.

RankProdIt: A web-interactive Rank Products analysis tool.

Author information

1
Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK. e.laing@surrey.ac.uk.

Abstract

BACKGROUND:

The first objective of a DNA microarray experiment is typically to generate a list of genes or probes that are found to be differentially expressed or represented (in the case of comparative genomic hybridizations and/or copy number variation) between two conditions or strains. Rank Products analysis comprises a robust algorithm for deriving such lists from microarray experiments that comprise small numbers of replicates, for example, less than the number required for the commonly used t-test. Currently, users wishing to apply Rank Products analysis to their own microarray data sets have been restricted to the use of command line-based software which can limit its usage within the biological community.

FINDINGS:

Here we have developed a web interface to existing Rank Products analysis tools allowing users to quickly process their data in an intuitive and step-wise manner to obtain the respective Rank Product or Rank Sum, probability of false prediction and p-values in a downloadable file.

CONCLUSIONS:

The online interactive Rank Products analysis tool RankProdIt, for analysis of any data set containing measurements for multiple replicated conditions, is available at: http://strep-microarray.sbs.surrey.ac.uk/RankProducts.

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