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BMC Gastroenterol. 2010 Aug 6;10:89. doi: 10.1186/1471-230X-10-89.

Reproductive life disorders in Italian celiac women. A case-control study.

Author information

1
Section of Hygiene, Department of Medical and Occupational Science, University of Foggia, Viale Pinto, 71000 Foggia, Italy.

Abstract

BACKGROUND:

The aim of this study is to explore the association between celiac disease and menstrual cycle, gestation and puerperal disorders.

METHODS:

The association between celiac disease and menstrual cycle, gestation and puerperal disorders in a sample of 62 childbearing age women (15-49 age) was assessed within an age and town of residence matched case-control study conducted in 2008. Main outcome measures were the presence of one or more disorders in menstrual cycle and the presence of one or more complication during pregnancy.

RESULTS:

62 celiac women (median age: 31.5, range: 17-49) and 186 healthy control (median age: 32.5, range: 15-49) were interviewed. A higher percentage of menstrual cycle disorders has been observed in celiac women. 19.4% frequency of amenorrhea was reported among celiac women versus 2.2% among healthy controls (OR = 33, 95% CI = 7.17-151.8;, p = 0.000). An association has been observed between celiac disease and oligomenorrhea, hypomenorrhea, dysmenorrhea and metrorrhagia (p < 0.05). The likelihood of having at least one complication during pregnancy has been estimated to be at least four times higher in celiac women than in healthy women (OR = 4.1, 95% CI = 2-8.6, p = 0.000). A significant correlation has emerged for celiac disease and threatened abortion, gestational hypertension, placenta abruption, severe anaemia, uterine hyperkinesia, intrauterine growth restriction (p < 0.001). A shorter gestation has on average been observed in celiac women together with a lower birth weight of celiac women babies (p < 0.001).

CONCLUSIONS:

The occurrence of a significant correlation between celiac disease and reproductive disorders could suggest to consider celiac disease diagnostic procedures (serological screening) in women affected by these disorders.

PMID:
20691041
PMCID:
PMC2928757
DOI:
10.1186/1471-230X-10-89
[Indexed for MEDLINE]
Free PMC Article

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