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Psychopharmacology (Berl). 2010 Dec;212(4):475-84. doi: 10.1007/s00213-010-1973-x. Epub 2010 Aug 6.

GABA(A) ρ receptor mechanisms in the rat amygdala and its role in the modulation of fear and anxiety.

Author information

1
Division of Neurosciences, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Apartado Postal 70-253, 04510, Mexico City, Mexico.

Abstract

RATIONALE:

Accumulating evidence for the presence of GABA(A) ρ receptors within the amygdala which differ from other members of the GABA(A) receptor family in both subunit composition and functional properties has been recently obtained.

OBJECTIVES:

This work was conducted to study whether GABA(A) ρ receptors may have a putative role in the amygdaloid modulation of fear and anxiety.

RESULTS:

It was found that the bilateral intra-amygdaloid administration (6-240 pmol/side) of (1,2,5,6-tetrahydropyridine-4-yl)methylphosphinic acid, a selective GABA(A) ρ receptor antagonist, reduced dose-dependently the exploration of the open arms of the elevated plus-maze without affecting locomotion and increased the plasma levels of corticosterone. In contrast, bicuculline in the dose range used (1.8-60 pmol/side) induced seizures, but had no effects on the exploration of the maze.

CONCLUSIONS:

It is suggested that GABA(A) ρ receptors may have a role in the amygdaloid modulation of fear and anxiety.

PMID:
20689940
DOI:
10.1007/s00213-010-1973-x
[Indexed for MEDLINE]

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