Format

Send to

Choose Destination
See comment in PubMed Commons below
Drug Des Devel Ther. 2010 Jul 21;4:139-45.

Eltrombopag--a novel approach for the treatment of chronic immune thrombocytopenic purpura: review and safety considerations.

Author information

1
Department of Haematology, Imperial Health Care NHS Trust, Hammersmith Hospital, London, UK. n.cooper@imperial.ac.uk

Abstract

Eltrombopag is one of a number of novel agents recently developed for use in the treatment of patients with immune thrombocytopenia (ITP). Rather than preventing destruction of platelets, these agents increase the production of platelets, presumably overwhelming the immune system resulting in normal platelet counts in individuals refractory to or dependent on other therapies. These treatments are well tolerated and in randomized controlled trials show an improvement in platelet counts and a reduction in bleeding in refractory patients. This article summarizes the development of this new class of drug and evaluates the safety and efficacy of eltrombopag in patients with ITP.

KEYWORDS:

eltrombopag; immune thrombocytopenic purpura; thrombopoietin

PMID:
20689640
PMCID:
PMC2915538
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Dove Medical Press Icon for PubMed Central
    Loading ...
    Support Center