Format

Send to

Choose Destination
Science. 2010 Aug 6;329(5992):676-9. doi: 10.1126/science.1188836.

Host phylogeny constrains cross-species emergence and establishment of rabies virus in bats.

Author information

1
Rabies Team, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. dstrike@uga.edu

Abstract

For RNA viruses, rapid viral evolution and the biological similarity of closely related host species have been proposed as key determinants of the occurrence and long-term outcome of cross-species transmission. Using a data set of hundreds of rabies viruses sampled from 23 North American bat species, we present a general framework to quantify per capita rates of cross-species transmission and reconstruct historical patterns of viral establishment in new host species using molecular sequence data. These estimates demonstrate diminishing frequencies of both cross-species transmission and host shifts with increasing phylogenetic distance between bat species. Evolutionary constraints on viral host range indicate that host species barriers may trump the intrinsic mutability of RNA viruses in determining the fate of emerging host-virus interactions.

Comment in

PMID:
20689015
DOI:
10.1126/science.1188836
[Indexed for MEDLINE]
Free full text

Publication types, MeSH terms, Substances, Secondary source ID, Grant support

Publication types

MeSH terms

Substances

Secondary source ID

Grant support

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center