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Clin Cancer Res. 2010 Oct 1;16(19):4695-701. doi: 10.1158/1078-0432.CCR-10-0356. Epub 2010 Aug 5.

Wnt/beta-catenin signaling in T-cell immunity and cancer immunotherapy.

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1
Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.

Abstract

Wnt ligands are lipid-modified secreted glycoproteins that regulate embryonic development, cell fate specification, and the homeostasis of self-renewing adult tissues. In addition to its well-established role in thymocyte development, recent studies have indicated that Wnt/β-catenin signaling is critical for the differentiation, polarization, and survival of mature T lymphocytes. Here, we describe our current understanding of Wnt signaling in the biology of post-thymic T cells, and discuss how harnessing the Wnt/β-catenin pathway might improve the efficacy of vaccines, T-cell-based therapies, and allogeneic stem cell transplantation for the treatment of patients with cancer.

PMID:
20688898
PMCID:
PMC3393131
DOI:
10.1158/1078-0432.CCR-10-0356
[Indexed for MEDLINE]
Free PMC Article
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