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Clin Chim Acta. 2010 Nov 11;411(21-22):1606-10. doi: 10.1016/j.cca.2010.07.030. Epub 2010 Aug 2.

Biological variability of glycated hemoglobin.

Author information

1
Centro Interdipartimentale per la Riferibilità Metrologica in Medicina di Laboratorio (CIRME), Università degli Studi, Milano, Italy. federica.braga@studenti.unimi.it

Abstract

BACKGROUND:

The measurement of glycated hemoglobin (HbA(1c)) has a pivotal role in monitoring glycemic state in diabetic patients. Furthermore, the American Diabetes Association has recently recommended the use of HbA(1c) for diabetes diagnosis, but a clear definition of the clinically allowable measurement error is still lacking. Information on biological variability of the analyte can be used to achieve this goal.

METHODS:

We systematically reviewed the published studies on the biological variation of HbA(1c) to check consistency of available data in order to accurately define analytical goals.

RESULTS:

The nine recruited studies were limited by choice of analytic methodology, population selection, protocol application and statistical analyses.

CONCLUSIONS:

There is an urgent need to determine biological variability of HbA(1c) using a specific and traceable assay, appropriate protocol and appropriate statistical evaluation of data.

PMID:
20688052
DOI:
10.1016/j.cca.2010.07.030
[Indexed for MEDLINE]

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