Send to

Choose Destination
Trends Genet. 1991 Apr;7(4):119-25.

Dorsoventral pattern formation in Drosophila: signal transduction and nuclear targeting.

Author information

Department of Molecular Biology, Princeton University, NJ 08544.


The maternal determinants of dorsoventral polarity of the Drosophila embryo are derived from somatic and germ-line components of the egg chamber. During oogenesis, asymmetry seems to be established by a signal transduction process. This process is thought to provide the developing embryo with a ventral signal responsible for determining the embryonic axis. Through a set of interactions that may involve signal transduction and proteolytic cascade events, positional information is generated in the form of a graded distribution of dorsal protein in blastoderm nuclei. Different levels of dorsal protein result in asymmetric expression of zygotic genes that ultimately specify cell fate.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center