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Trends Genet. 1991 Apr;7(4):119-25.

Dorsoventral pattern formation in Drosophila: signal transduction and nuclear targeting.

Author information

1
Department of Molecular Biology, Princeton University, NJ 08544.

Abstract

The maternal determinants of dorsoventral polarity of the Drosophila embryo are derived from somatic and germ-line components of the egg chamber. During oogenesis, asymmetry seems to be established by a signal transduction process. This process is thought to provide the developing embryo with a ventral signal responsible for determining the embryonic axis. Through a set of interactions that may involve signal transduction and proteolytic cascade events, positional information is generated in the form of a graded distribution of dorsal protein in blastoderm nuclei. Different levels of dorsal protein result in asymmetric expression of zygotic genes that ultimately specify cell fate.

PMID:
2068782
[Indexed for MEDLINE]

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