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Expert Opin Pharmacother. 2010 Dec;11(17):2879-89. doi: 10.1517/14656566.2010.509344. Epub 2010 Aug 5.

Therapeutic management of premenstrual syndrome.

Author information

1
Departments of Obstetrics/Gynecology and Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA. freemane@mail.med.upenn.edu

Abstract

IMPORTANCE OF THE FIELD:

Premenstrual syndrome (PMS) is among the most common health problems reported by reproductive-age women. Estimates indicate that up to 25% of women may warrant treatment for the distress or impaired functioning associated with the symptoms.

AREAS COVERED IN THIS REVIEW:

The primary focus of this review is the clinical condition of PMS and randomized, placebo-controlled trials of PMS treatment. A literature search in PubMed was conducted for these topics. The most recent reports of specific treatments in controlled treatment studies and all meta-analyses were selected.

WHAT THE READER WILL GAIN:

Reports consistently indicate that serotonergic antidepressants reduce PMS symptoms compared to a placebo. Hormonal treatments are the most widely prescribed medical treatment. Some oral contraceptives and gonadotropin-releasing hormone analogs have demonstrated efficacy, particularly for women who want contraception and PMS symptom control. Numerous non-pharmacologic treatments are utilized, but efficacy is reported only for calcium supplements, Vitex agnus castus (chasteberry), and cognitive-behavioral therapies. Further research to develop new therapies for the 40% of women with PMS who do not respond to the currently available treatments is needed.

TAKE HOME MESSAGE:

There are treatments with demonstrated efficacy for PMS, and the majority of women can be helped.

PMID:
20687778
DOI:
10.1517/14656566.2010.509344
[Indexed for MEDLINE]

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