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Ann Neurol. 2010 Oct;68(4):535-40. doi: 10.1002/ana.22015.

Lack of shunt response in suspected idiopathic normal pressure hydrocephalus with Alzheimer disease pathology.

Author information

1
Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.

Abstract

To determine the impact of cortical Alzheimer disease pathology on shunt responsiveness in individuals treated for idiopathic normal pressure hydrocephalus (iNPH), 37 patients clinically diagnosed with iNPH participated in a prospective study in which performance on neurologic, psychometric, and gait measures before and 4 months after shunting was correlated with amyloid β plaques, neuritic plaques, and neurofibrillary tangles observed in cortical biopsies obtained during shunt insertion. No complications resulted from biopsy acquisition. Moderate to severe pathology was associated with worse baseline cognitive performance and diminished postoperative improvement on NPH symptom severity scales, gait measures, and cognitive instruments compared to patients lacking pathology.

PMID:
20687117
PMCID:
PMC2964442
DOI:
10.1002/ana.22015
[Indexed for MEDLINE]
Free PMC Article

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