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Mult Scler. 2010 Oct;16(10):1248-51. doi: 10.1177/1352458510376956. Epub 2010 Aug 4.

Multiple sclerosis-associated retrovirus and progressive disability of multiple sclerosis.

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Section of Neurology, Department of Neurosciences, University of Sassari, Sassari, Italy.


Retrovirus-like particles containing the multiple sclerosis-associated retrovirus RNA, significantly found in the cerebrospinal fluid of patients with multiple sclerosis, have been preliminarily associated with a short-term poor clinical and radiological prognosis of the disease. We asked whether these prognostic indications are still measurable after a long-term clinical evaluation (10 years). Our 10-year blind observational study confirms that the presence of multiple sclerosis-associated retrovirus in the cerebrospinal fluid of early multiple sclerosis patients is associated with a significantly greater rate of relapse-unrelated unremitting disability and secondary progression of the disease.

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