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Microbes Infect. 2010 Oct;12(11):791-8. doi: 10.1016/j.micinf.2010.05.008. Epub 2010 Jun 2.

Outer membrane vesicles function as offensive weapons in host-parasite interactions.

Author information

1
Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita-Osaka 565-0871, Japan. amanoa@dent.osaka-u.ac.jp

Abstract

Outer membrane vesicles (OMVs), ubiquitously shed from Gram-negative bacteria, contain various virulence factors such as toxins, proteases, adhesins, and lipopolysaccharide, which are utilized to establish a colonization niche, modulate host defense and response, and impair host cell function. Thus, OMVs can be considered as a type of bacterial offensive weapon. This review discusses the entry mechanism of OMVs into host cells as well as their etiological roles in host-parasite interactions.

PMID:
20685339
DOI:
10.1016/j.micinf.2010.05.008
[Indexed for MEDLINE]

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