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Pflugers Arch. 2010 Nov;460(6):953-64. doi: 10.1007/s00424-010-0865-6. Epub 2010 Aug 4.

Physiological carbon dioxide, bicarbonate, and pH sensing.

Author information

1
Department of Pharmacology, Weill Cornell Medical College, Cornell University, New York, USA.

Abstract

In biological systems, carbon dioxide exists in equilibrium with bicarbonate and protons. The individual components of this equilibrium (i.e., CO₂, HCO₃⁻, and H(+)), which must be sensed to be able to maintain cellular and organismal pH, also function as signals to modulate multiple physiological functions. Yet, the molecular sensors for CO₂/HCO₃⁻/pH remained unknown until recently. Here, we review recent progress in delineating molecular and cellular mechanisms for sensing CO₂, HCO₃⁻, and pH.

PMID:
20683624
PMCID:
PMC2967379
DOI:
10.1007/s00424-010-0865-6
[Indexed for MEDLINE]
Free PMC Article

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