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Cell Stem Cell. 2010 Aug 6;7(2):135-6. doi: 10.1016/j.stem.2010.07.002.

Dying alone: a tale of rho.

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The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.

Abstract

In this issue of Cell Stem Cell, Chen et al. (2010) and Ohgushi et al. (2010) report that Rho-mediated actomyosin contractility underlies the proclivity of human embryonic stem cells to undergo apoptosis upon dissociation or during low-density propagation, a property that challenges their in vitro isolation and manipulation.

PMID:
20682437
DOI:
10.1016/j.stem.2010.07.002
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