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Neurobiol Dis. 2010 Dec;40(3):531-43. doi: 10.1016/j.nbd.2010.07.013. Epub 2010 Aug 2.

Early changes in the hypothalamic region in prodromal Huntington disease revealed by MRI analysis.

Collaborators (307)

Paulson H, Elbert M, Nopoulos P, Rodnitzky R, Uc E, Beglinger L, Duff K, Magnotta VA, Cross S, Doucette N, Juhl A, Schumacher J, Kimble M, Ryan P, Wood J, Epping E, Thomsen T, Ames D, Chiu E, Chua P, Yastrubetskaya O, Dingjan P, Draper K, Georgiou-Karistianis N, Goh A, Komiti A, Raymond L, Santos RD, Decolongon J, Rosenblatt A, Ross CA, Agarwal A, Shpritz B, Welsh C, Mallonee WM, Suter G, Samii A, Lipe H, Weaver K, Jones R, Harrison J, Ingram C, Wood-Siverio C, Factor SA, Testa C, Barker RA, Mason S, McCusker E, Griffith J, Bibb B, Richardson K, Landwehrmeyer BG, Ecker D, Weydt P, Orth M, Süssmuth S, Barth K, Trautmann S, Quaid K, Wesson M, Wojcieszek J, Guttman M, Sheinberg A, Singer A, Stober J, Perlman S, Johnson A, Geschwind MD, Gooblar J, Guzijan M, Warner T, Kloppel S, Burrows M, Andrews T, Rosser E, Tabrizi S, Rosser A, Naji J, Price K, Handley OJ, Como P, Chesire A, Marshall F, Wodarski M, Suchowersky O, Furtado S, Klimek ML, Rosas D, Young A, Bender A, Zaleta A, Panegyres P, Connor C, Vuletich E, Woodman M, Zombor R, Perlmutter J, Barton S, Simpson SA, Matheson K, Ure A, Craufurd D, Fullam R, Macleod R, Sollom A, Howard E, Mazzoni P, Marder K, Moskowitz C, Wasserman P, Seeberger L, Diamond A, Erickson D, Miracle D, Montellano S, Kumar R, Wheelock V, Tempkin T, Marsano J, Sanders M, Baynes K, Jankovic J, Hunter C, Ondo W, de Yebenes JG, Garde MB, Fatas M, Martinez A, Nance M, Radtke D, Tupper D, Martin W, King P, Wieler M, Sran S, Paulsen J, Langbehn D, Johnson H, Magnotta V, Nopoulos P, Pierson R, Williams J, Aylward E, Biglan K, Erwin C, Guttman M, Hayden M, Leavitt B, MacDonald M, Nance M, Rao S, Ross CA, Stout J, Blanchard S, Dudler A, Henneberry M, Montross K, O'Brien P, Mills JA, Wang C, Werling-Witkoske C, Adams W, Anderson K, Schumacher J, Thompson S, Leavitt B, DiDonato S, Juhl A, Mattson W, Petersen A, Tabrizi S, Harrington D, Westervelt H, Moser D, Smith M, Cross S, Mills J, Stout J, Campbell C, Davison J, Queller S, Williams J, Clark LA, Leserman A, O'Rourke J, Brossman B, Ro E, Ready R, Vaccarino A, Farias S, Carlozzi N, Nehl C, MacDonald M, Gusella J, Myers R, Hayden M, Wassink T, Epping E, Pierson R, Potkin S, Toga A, Aylward E, Weaver K, Beg MF, Miller M, Reading S, Ross CA, Nopoulos P, Axelson E, Bockholt J, Vitense K, Ross CA, Magnotta V, Helmer K, Lim K, Mori S, Song A, Turner J, Rao S, Beall E, Koenig K, Lowe M, Phillips M, Reece C, Zimbelman J, Biglan K, Duff K, Fedorowicz J, Robinson R, Craufurd D, van Duijn E, Langbehn D, Mills J, Wang C, Oakes D, Bourgeois K, Whitlock K, Nance M, Vik S, Leserman A, Adams W, Anderson C, Schumaker J, Doucette N, Reynolds N, Erwin C, Coryell W, Williams J, Nance M, Johnson H, Smith J, Connell RJ, Bockholt J, Weber J, Werling C, Anderson K, Dudler A, Schumacher J, Thompson S, Kayson E, Julian-Baros E, Blanchard S, O'Brien P, Henneberry M, Montross K, Bourgeois K, Covert C, Daigneault S, Julian-Baros E, Meyers K, Rothenburgh K, Olsen B, Orme C, Ross T, Simone M, Weber J, Zhao H, Stout JC, Queller S, Johnson SA, Campbell JC, Peters E, Carlozzi NE, Green T, Swain SN, Caughlin D, Ward-Bluhm B, Whitlock K, Paulsen J, Vik S, Anderson C, Chesire A, Agarwal A, Griffith J, Barth K, Trautman S, Guzijan M, Naji J, Julian-Baros E, Kayson E, Reynolds N, Stout J, Paulsen J, Coryell W, Stout J, Erwin C, Hersch S.

Author information

1
Centre for Mathematical Sciences, Lund University, Sweden.

Abstract

Huntington disease (HD) is a fatal neurodegenerative disorder caused by an expanded CAG repeat. Its length can be used to estimate the time of clinical diagnosis, which is defined by overt motor symptoms. Non-motor symptoms begin before motor onset, and involve changes in hypothalamus-regulated functions such as sleep, emotion and metabolism. Therefore we hypothesized that hypothalamic changes occur already prior to the clinical diagnosis. We performed voxel-based morphometry and logistic regression analyses of cross-sectional MR images from 220 HD gene carriers and 75 controls in the Predict-HD study. We show that changes in the hypothalamic region are detectable before clinical diagnosis and that its grey matter contents alone are sufficient to distinguish HD gene carriers from control cases. In conclusion, our study shows, for the first time, that alterations in grey matter contents in the hypothalamic region occur at least a decade before clinical diagnosis in HD using MRI.

PMID:
20682340
PMCID:
PMC2955781
DOI:
10.1016/j.nbd.2010.07.013
[Indexed for MEDLINE]
Free PMC Article
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