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Anal Bioanal Chem. 2010 Nov;398(6):2535-49. doi: 10.1007/s00216-010-4018-8. Epub 2010 Aug 1.

Sizing up the future of microRNA analysis.

Author information

1
Department of Chemistry, Institute for Genomic Biology, and Micro and Nanotechnology Laboratory, University of Illinois, Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL 61801, USA.

Abstract

In less than 20 years, our appreciation for micro-RNA molecules (miRNAs) has grown from an original, curious observation in worms to their current status as incredibly important global regulators of gene expression that play key roles in many transformative biological processes. As our understanding of these small, non-coding transcripts continues to evolve, new approaches for their analysis are emerging. In this critical review we describe recent improvements to classical methods of detection as well as innovative new technologies that are poised to help shape the future landscape of miRNA analysis.

PMID:
20680616
PMCID:
PMC2965821
DOI:
10.1007/s00216-010-4018-8
[Indexed for MEDLINE]
Free PMC Article

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