Format

Send to

Choose Destination
Genes Dev. 2010 Aug 1;24(15):1580-9. doi: 10.1101/gad.1941710.

The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor.

Author information

1
Department of Oncological Sciences, Mount Sinai School of Medicine, New York, New York 10029, USA. james.manfredi@mssm.edu

Erratum in

  • Genes Dev. 2010 Sep 15;24(18):2105.

Abstract

Mdm2 has been well characterized as a negative regulator of the tumor suppressor p53. Recent studies have shown that Mdm2 is activated in response to a variety of oncogenic pathways independent of p53. Although its role as an oncogene via suppression of p53 function remains clear, growing evidence argues for p53-independent effects, as well as the remarkable possibility that Mdm2 has tumor suppressor functions in the appropriate context. Hence, Mdm2 is proving to be a key player in human cancer in its own right, and thus an important target for therapeutic intervention.

PMID:
20679392
PMCID:
PMC2912554
DOI:
10.1101/gad.1941710
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center