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Bioinformatics. 2010 Oct 1;26(19):2496-7. doi: 10.1093/bioinformatics/btq442. Epub 2010 Aug 2.

The CoFactor database: organic cofactors in enzyme catalysis.

Author information

  • 1EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK. julia.fischer@ebi.ac.uk

Abstract

MOTIVATION:

Organic enzyme cofactors are involved in many enzyme reactions. Therefore, the analysis of cofactors is crucial to gain a better understanding of enzyme catalysis. To aid this, we have created the CoFactor database.

RESULTS:

CoFactor provides a web interface to access hand-curated data extracted from the literature on organic enzyme cofactors in biocatalysis, as well as automatically collected information. CoFactor includes information on the conformational and solvent accessibility variation of the enzyme-bound cofactors, as well as mechanistic and structural information about the hosting enzymes.

AVAILABILITY:

The database is publicly available and can be accessed at http://www.ebi.ac.uk/thornton-srv/databases/CoFactor.

PMID:
20679331
PMCID:
PMC2944199
DOI:
10.1093/bioinformatics/btq442
[PubMed - indexed for MEDLINE]
Free PMC Article
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