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Int J Geriatr Psychiatry. 2011 Jul;26(7):702-10. doi: 10.1002/gps.2584. Epub 2010 Jul 30.

The interaction between cerebrovascular disease and neuroticism in late-life depression: a cross-sectional study.

Author information

1
Department of Psychiatry, Nijmegen Centre for Evidence-Based Practice, Radboud University Nijmegen Medical Centre, The Netherlands. l.wouts@psy.umcn.nl

Abstract

OBJECTIVE:

Vascular disease and neuroticism are both risk factors for late-life depression. In this study we examined the interaction between vascular disease and neuroticism as determinants of clinically relevant depressive symptoms (CRDS) in late-life.

METHODS:

Multivariate logistic regression in a survey of 1396 population-dwelling people aged ≥70 years. CRDS were defined as scoring ≥16 on the CES-D. Vascular disease was categorised into four levels: none, ≥2 vascular risk factors, cardiac disease or stroke.

RESULTS:

Neuroticism was strongly associated with CRDS in women (OR: 1.6, 95% CI: 1.4-1.8). In men vascular disease interacted negatively but significantly with neuroticism (cardiac disease by neuroticism: OR: 0.8, 95% CI: 0.6-0.9; stroke by neuroticism: OR: 0.8, 95% CI: 0.6-0.96) when predicting CRDS.

CONCLUSIONS:

In men vascular disease attenuates the predictive value of neuroticism in CRDS, which might be mediated by apathy caused by cerebrovascular disease.

PMID:
20677172
DOI:
10.1002/gps.2584
[Indexed for MEDLINE]

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