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Nat Methods. 2010 Sep;7(9):733-6. doi: 10.1038/nmeth.1487. Epub 2010 Aug 1.

Mechanical regulation of cell function with geometrically modulated elastomeric substrates.

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  • 1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.

Erratum in

  • Nat Methods. 2011 Feb;8(2):184.

Abstract

We report the establishment of a library of micromolded elastomeric micropost arrays to modulate substrate rigidity independently of effects on adhesive and other material surface properties. We demonstrated that micropost rigidity impacts cell morphology, focal adhesions, cytoskeletal contractility and stem cell differentiation. Furthermore, early changes in cytoskeletal contractility predicted later stem cell fate decisions in single cells.

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PMID:
20676108
PMCID:
PMC3069358
DOI:
10.1038/nmeth.1487
[PubMed - indexed for MEDLINE]
Free PMC Article
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