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Nat Neurosci. 2010 Sep;13(9):1047-9. doi: 10.1038/nn.2609. Epub 2010 Aug 1.

Regulation of fast-spiking basket cell synapses by the chloride channel ClC-2.

Author information

1
Department of Anatomy and Neurobiology, University of California, Irvine, California, USA. foldy@stanford.edu

Abstract

Parvalbumin-expressing, fast-spiking basket cells are important for the generation of synchronous, rhythmic population activities in the hippocampus. We found that GABAA receptor-mediated synaptic inputs from murine parvalbumin-expressing basket cells were selectively modulated by the membrane voltage- and intracellular chloride-dependent chloride channel ClC-2. Our data reveal a previously unknown cell type-specific regulation of intracellular chloride homeostasis in the perisomatic region of hippocampal pyramidal neurons.

PMID:
20676104
PMCID:
PMC2928876
DOI:
10.1038/nn.2609
[Indexed for MEDLINE]
Free PMC Article

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