Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Neurosci. 2010 Sep;13(9):1056-8. doi: 10.1038/nn.2610. Epub 2010 Aug 1.

Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy.

Author information

1
Department of Cell Biology, The Scripps Research Institute, La Jolla, California, USA.

Abstract

We found the voltage-gated K+ channel Kv12.2 to be a potent regulator of excitability in hippocampal pyramidal neurons. Genetic deletion and pharmacologic block of Kv12.2 substantially reduced the firing threshold of these neurons. Kv12.2-/- (also known as Kcnh3-/-) mice showed signs of persistent neuronal hyperexcitability including frequent interictal spiking, spontaneous seizures and increased sensitivity to the chemoconvulsant pentylenetetrazol.

PMID:
20676103
PMCID:
PMC2928878
DOI:
10.1038/nn.2610
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Support Center