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Nat Chem Biol. 2010 Sep;6(9):641-3. doi: 10.1038/nchembio.418. Epub 2010 Aug 1.

A copper-containing oxidase catalyzes C-nitrosation in nitrosobenzamide biosynthesis.

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1
Department of Biotechnology, Graduate School of Agriculture and Life Sciences, University of Tokyo, Tokyo, Japan.

Abstract

Although C-nitroso aromatic compounds have several bioactivities of medicinal interest, the biosynthetic enzymes involved in C-nitrosation have remained unknown until now. Here, we report the entire biosynthesis pathway of 4-hydroxy-3-nitrosobenzamide in Streptomyces murayamaensis, in which a tyrosinase-like copper-containing monooxygenase is responsible for the C-nitrosation. This finding indicates diverse catalytic functions of tyrosinase-like copper-containing monooxygenases in nature.

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PMID:
20676084
DOI:
10.1038/nchembio.418
[Indexed for MEDLINE]

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