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Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14657-61. doi: 10.1073/pnas.1009412107. Epub 2010 Jul 30.

Efficient reprogramming of adult neural stem cells to monocytes by ectopic expression of a single gene.

Author information

1
Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden.

Abstract

Neural stem cells have a broad differentiation repertoire during embryonic development and can be reprogrammed to pluripotency comparatively easily. We report that adult neural stem cells can be reprogrammed at very high efficiency to monocytes, a differentiated fate of an unrelated somatic lineage, by ectopic expression of the Ets transcription factor PU.1. The reprogrammed cells display a marker profile and functional characteristics of monocytes and integrate into tissues after transplantation. The failure to reprogram lineage-committed neural cells to monocytes with PU.1 suggests that neural stem cells are uniquely amenable to reprogramming.

PMID:
20675585
PMCID:
PMC2930460
DOI:
10.1073/pnas.1009412107
[Indexed for MEDLINE]
Free PMC Article
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