Format

Send to

Choose Destination
Cell Metab. 2010 Aug 4;12(2):105-6. doi: 10.1016/j.cmet.2010.07.004.

Transfer of cholesterol by the NPC team.

Author information

1
Group on Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, AB T6G 2S2, Canada. jean.vance@ualberta.ca

Abstract

The mechanisms of intracellular cholesterol transport are largely unknown. In this issue of Cell Metabolism, Wang et al. (2010) identify amino acid residues on the lumenal lysosomal protein Niemann-Pick C2 (NPC2) that are required for intralysosomal transfer of endocytosed cholesterol to membrane-bound NPC1 via a process that avoids movement of hydrophobic cholesterol through the aqueous phase.

PMID:
20674853
DOI:
10.1016/j.cmet.2010.07.004
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center