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Biochim Biophys Acta. 2011 Feb;1812(2):202-12. doi: 10.1016/j.bbadis.2010.07.017. Epub 2010 Jul 30.

Assessment of evidence for a protective role of vitamin D in multiple sclerosis.

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1
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. heather.hanwell@gmail.com

Abstract

Evidence for a role of vitamin D insufficiency in determining risk in Multiple Sclerosis (MS) is supported by studies in both pediatric- and adult-onset patients. The potential role of vitamin D in modulating MS disease activity is an area of active clinical trials research, and the possibility of primary disease prevention with vitamin D supplementation in early life is an emerging concept. With Sir Austin Bradford Hill's criteria as a framework, the present review assesses the evidence for a causal relationship between vitamin D insufficiency and the pathobiology of MS, and discusses rationale for future clinical trials with vitamin D.

PMID:
20674744
DOI:
10.1016/j.bbadis.2010.07.017
[Indexed for MEDLINE]
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