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Cytokine Growth Factor Rev. 2010 Aug;21(4):287-98. doi: 10.1016/j.cytogfr.2010.06.001. Epub 2010 Jul 31.

BMP signaling in vascular development and disease.

Author information

1
Department of Cell and Developmental Biology and Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Abstract

Genetic and functional studies indicate that common components of the bone morphogenetic protein (BMP) signaling pathway play critical roles in regulating vascular development in the embryo and in promoting vascular homeostasis and disease in the adult. However, discrepancies between in vitro and in vivo findings and distinct functional properties of the BMP signaling pathway in different vascular beds, have led to controversies in the field that have been difficult to reconcile. This review attempts to clarify some of these issues by providing an up to date overview of the biology and genetics of BMP signaling relevant to the intact vasculature.

PMID:
20674464
PMCID:
PMC2939258
DOI:
10.1016/j.cytogfr.2010.06.001
[Indexed for MEDLINE]
Free PMC Article

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