Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2010 Sep 1;20(17):5065-8. doi: 10.1016/j.bmcl.2010.07.034. Epub 2010 Jul 13.

Synthesis of selenophene derivatives as novel CHK1 inhibitors.

Author information

1
Development Center for Biotechnology, Xizhi City, Taipei County, Taiwan. pchong@mail.dcb.org.tw

Abstract

A series of selenophene derivatives 3 were synthesized as potential CHK1 inhibitors. The effects of substitution on the 4'- or 5'-position of selenophene moiety and shifting the hydroxyl group position on C6- phenolic ring of oxindole were explored. This study led to the discovery of the most potent CHK1 inhibitors 29-33 and 39-43, which had IC(50) values in the subnanomolar range.

PMID:
20674356
DOI:
10.1016/j.bmcl.2010.07.034
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center