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Zhongguo Fei Ai Za Zhi. 2010 Feb;13(2):132-5. doi: 10.3779/j.issn.1009-3419.2010.02.10.

[BSD2000 deep hyperthermia combined with chemotherapy of PT regimen in patients with non-small cell lung cancer].

[Article in Chinese]

Author information

1
Department of Medical Oncology, Liaocheng People's Hospital, Liaocheng 252000, China. ymx1405@sina.com

Abstract

BACKGROUND AND OBJECTIVE:

The aim of this study is to determine the short-term efficacy, toxicity and the rate of life-quality improvement of BSD2000 deep hyperthermia combined with chemotherapy of PT regimen in patients with non-small cell lung cancer (NSCLC) by comparation with PT regimen alone.

METHODS:

Sixty patients with NSCLC were randomly divided into the treatment group and control group, with 30 each. The treatment group was treated with chemotherapy (paclitaxel: 135 mg/m2 ivdirp 3 h qd d1+cisplatin: 20 mg/m2 ivdirp qd d1-5) in combination with BSD2000 deep hyperthermia, and hyperthermia was positioned precisely and maintained for 60 min (2 times a cycle: d1, 4 after the end of chemotherapy within two hours). The control group was treated with chemotherapy alone. Treatment response in both groups were evaluated as well as side-effects after 3 cycles. By observing the results, comparing response rate, toxic side effects and quality of life improvement rate in two groups.

RESULTS:

The efficiency and the rate of life-quality improvement in the treatment group were 63.33%, 76.67% respectively, and 36.67%, 40.00% in the control group respectively. There were significant differences between two groups (P < 0.05). The main side-effects were myelosuppression and gastrointestinal reactions, no significant difference between two groups (P > 0.05).

CONCLUSION:

BSD2000 deep hyperthermia combined with chemotherapy in patients with NSCLC can significantly increase the efficacy, response rate and quality of life improvement and without increasing side-effects compared to chemotherapy alone.

[Indexed for MEDLINE]
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