Format

Send to

Choose Destination
Neuron. 2010 Jul 29;67(2):294-307. doi: 10.1016/j.neuron.2010.06.017.

Thalamic gating of corticostriatal signaling by cholinergic interneurons.

Author information

1
Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Abstract

Salient stimuli redirect attention and suppress ongoing motor activity. This attentional shift is thought to rely upon thalamic signals to the striatum to shift cortically driven action selection, but the network mechanisms underlying this interaction are unclear. Using a brain slice preparation that preserved cortico- and thalamostriatal connectivity, it was found that activation of thalamostriatal axons in a way that mimicked the response to salient stimuli induced a burst of spikes in striatal cholinergic interneurons that was followed by a pause lasting more than half a second. This patterned interneuron activity triggered a transient, presynaptic suppression of cortical input to both major classes of principal medium spiny neuron (MSN) that gave way to a prolonged enhancement of postsynaptic responsiveness in striatopallidal MSNs controlling motor suppression. This differential regulation of the corticostriatal circuitry provides a neural substrate for attentional shifts and cessation of ongoing motor activity with the appearance of salient environmental stimuli.

PMID:
20670836
PMCID:
PMC4085694
DOI:
10.1016/j.neuron.2010.06.017
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center