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J Am Geriatr Soc. 2010 Sep;58(9):1715-20. doi: 10.1111/j.1532-5415.2010.03006.x.

The effect of medication use on urinary incontinence in community-dwelling elderly women.

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1
Department of Pharmacy and Therapeutics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Abstract

OBJECTIVES:

To evaluate whether use of certain medications with potential urological effects is associated with development of incident urinary incontinence in community-resident older women.

DESIGN:

Longitudinal cohort study.

SETTING:

Pittsburgh, PA, and Memphis, TN.

PARTICIPANTS:

Nine hundred fifty-nine healthy black and white women aged 65 and older enrolled in the Health, Aging and Body Composition Study without baseline (Year 1) self-reported urinary incontinence.

MEASUREMENTS:

Use of alpha blockers, anticholinergics, central nervous system medications (opioids, benzodiazepines, antidepressants, antipsychotics), diuretics (thiazide, loop, potassium sparing), and estrogen (all dosage forms) was determined during Year 3 interviews. Self-reported incident (≥ weekly) incontinence in during the previous 12 months was assessed at Year 4 interviews.

RESULTS:

Overall, 20.5% of these women reported incident incontinence at Year 4 (3 years from baseline). The most common medication used with potential urological activity was a thiazide diuretic (24.3%), followed by estrogen (22.2%); alpha blockers were the least commonly used (2.3%). Multivariable logistic regression analyses revealed that current users of alpha blockers (adjusted odds ratio (AOR)=4.98, 95% confidence interval (CI)=1.96-12.64) and estrogen (AOR=1.60, 95% CI=1.08-2.36) had a greater risk of urinary incontinence than nonusers. There was no greater risk (P>.05) of urinary incontinence with the current use of anticholinergics, central nervous system medications, or diuretics. No statistically significant race-by-medication use interactions were found (all P>.05).

CONCLUSION:

These results corroborate earlier reports that, in elderly women, use of alpha blockers or estrogens is associated with risk of self-reported incident urinary incontinence.

PMID:
20670377
PMCID:
PMC2945433
DOI:
10.1111/j.1532-5415.2010.03006.x
[Indexed for MEDLINE]
Free PMC Article
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