Format

Send to

Choose Destination
Mov Disord. 2010 Sep 15;25(12):1973-6. doi: 10.1002/mds.23163.

LRRK2 variation and Parkinson's disease in African Americans.

Author information

1
Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida 32224, USA. ross.owen@mayo.edu

Abstract

The global impact of LRRK2 mutations is yet to be realized with a lack of studies in specific ethnic groups, including those of Asian and African descent. Herein, we investigated the frequency of common LRRK2 variants by complete exon sequencing in a series of publicly available African American Parkinson's disease patients. Our study identified three novel synonymous exonic variants and 13 known coding variations; however, there did not appear to be any frequent (>5%) pathogenic mutations. Given the ethnic-specific LRRK2 variation previously identified in PD further studies in under-represented populations are warranted.

PMID:
20669299
PMCID:
PMC2939165
DOI:
10.1002/mds.23163
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center